|
KMID : 0370019870010000098
|
|
Chung-Ang Journal of Pharmacal Sciences
1987 Volume.1 No. 0 p.98 ~ p.105
|
|
|
Effects of desferioxamine B and D-penicillamine on the carrageenin induced inflammation in rats pretreated with Fe(Ⅲ) Cu(Ⅱ)
|
|
조인구/Cho, In Ku
허인회/Huh, In Hoi
|
|
|
Abstract
|
|
|
|
Edema volume, serum copper level, serum iron level and serum cerulopasmin activity was observed in rats pretreated with Fe(Ⅲ). Cu(Ⅱ) for 3 days followed by the administration of their chelating agents desferrioxamine B and D-penicillamine respectively. The results are as follows; 1) Edema volume was decreased significantly in rate pretreared with Fe(Ⅲ). Cu(Ⅱ) for 3 days after carrageenin injection. Serum copper and serum ceruloplasmin activity was decreased also, but serm iron level was not changed significantly. 2) Significant decrease of edema volume was observed followed by the administration of desferrioxamine B in rats edema induced by carrageenin injectin. Serum copper level and serum ceruloplasmin activity was decredsed also. However, significant increase of edema volume was observed followed by the administration of D-penicillamine. Serum copper and serum ceruloplasmin activity was increased also, but serm iron level was not changed significantly. 3) Edema volume was decresed significantly followed by the administration of disferrioxamine B in rats pretreated with Fe(Ⅲ) for 3 days. Serum copper level, serum ceruloplasmin activity was decreased also, but serm iron level was not changed aignificantly. However, edema volume was increased significantly followed by the administration of D-penicillamine in rats pretreated with Cu(Ⅱ) for 3 days. Serum copper level, serum ceruloplasmin activity was increased also, but serum iron level was not changed significantly.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|